Main Points of Coronary Artery Disease in Chronic Kidney Disease

Cardiovascular diseases are the most common cause of mortality and morbidity in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) receiving hemodialysis and peritoneal dialysis. Beside traditional risk factors including hypertension, diabetes, dyslipidemia, advanced age novel risk factors such as endothelial dysfunction, hyperphosphatemia, hyperparathyroidism, vascular calcification, increased oxidative stress and inflammation are highly prevalent and seem to play a more important role for vascular disease in CKD and ESRD patients compared to general population. This review briefly discuss classical and recent epidemiologic, pathophysiologic and clinical aspects of coronary artery disease in ESRD patients.