On-a-chip genotoxicity assay-application to high-throughput screening biochips

We present a cell array biochip dedicated to toxicological and high-throughput drug screening applications, on which are performed genotoxity analysis using micronucleus test. This cell biochip is an array of microwells optimized for living cell culture (Fig.1-a). Topographical aspects are exploited in order to control the distribution and the positioning of the cells on the biochip [1,2]. Such a miniaturized cell-based device is of great interest, in terms of cost and time, for pharmacological applications [3].