Abstract 20349: The Protective Effect of Estimated Training Status Against Oxidative Stress and High Blood Pressure Values in Middle-Aged and Older Women

The purpose of this study was to compare the association between pro and antioxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of 155 females (67.14±6.63 years). Participants were submitted to a physical examination to evaluate estimated TS throughout general functional fitness index (GFFI) by “Functional Fitness Battery Test”; systolic and diastolic BP (SBP and DPB) values; to collect plasma blood samples for pro-oxidant and antioxidant activity analysis and nitrite concentrations. Participants were divided according to age as middle-aged group ( vs TS3 = 2.29±0.74 nmol/mg protein) and glutathione peroxidase (TS1= 0.55±0.18 vs TS3= 0.42±0.11nmol/min/mL), when compared with TS3. In the older group, TS1 presented higher lipoperoxidation (TS1= 147.00±74.99 vs TS2= 92.65±58.98 and TS3= 93.55±39.59 nmol/mg protein), higher protein oxidation (TS=2.75±0.88 vs TS3= 2.09±0.67nmol/mg protein), lower nitrite concentration (TS1=0.49±0.32 and TS2=0.4±0.23 vs TS3=0.78±0.62nmol/L), higher SBP (TS1=129.27±13.62 vs TS=119.98±12.13 and TS3=119.98±9.83 mmHg) and also higher DBP (TS1=79.16±8.16 vs TS3=71.18±7.63 mmHg), compared with TS2 or TS3. These results suggest that good levels of estimated TS may be associated with lower oxidative stress and higher nitrite concentration, which contribute to increase NO bioavailability and maintenance of normal or reduced blood pressure values, especially in older group.