1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl group, a potential 5′-O-protecting group for solid-phase RNA synthesis

Abstract 1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5′-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2′-hydroxyl protecting group. The TES group can be selectively introduced to the 5′-hydroxy group of nucleosides and can be easily removed by 0.1M tetrabutylammonium fluoride or 0.01M hydrochloric acid.