Combination of Oxaliplatin and Vit.E-TPGS in Lipid Nanosystem for Enhanced Therapeutic Efficacy in Colon Cancers

Yanlei Wang,Xiang Zhang,Wenqiang Zhang,Hao Dong,Wenjie Zhang,Jiajia Mao,Yong Dai

Combination of Oxaliplatin and Vit.E-TPGS in Lipid Nanosystem for Enhanced Therapeutic Efficacy in Colon Cancers

2018

Yanlei Wang
Xiang Zhang
Wenqiang Zhang
Hao Dong
Wenjie Zhang
Jiajia Mao
Yong Dai

Purpose The main aim of present study was to prepare the oxaliplatin (OXL)-loaded D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)-based lipid nanoparticles to enhance the anticancer effect in colon cancer cells.

Keywords:

Cancer research
Polyethylene glycol
Colorectal cancer
Biochemistry
Oxaliplatin
Chemistry
Controlled release
In vitro
IC50
In vivo
Apoptosis
Cancer cell

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