ASSOCIATION OF INTERLEUKIN-10 GENE PROMOTER POLYMORPHISM IN ACUTE CORONARY SYNDROME PATIENTS AND THEIR FIRST DEGREE RELATIVES

Inflammation plays an important role in the pathogenesis of acute coronary syndrome (ACS). Recent studies have shown that interleukin (IL)-10, an anti inflammatory cytokine with pleiotropic properties involves in the progression of the disease, but the relationship between the genetic variants of IL-10 has not been extensively studied in the ACS patients and their first degree relatives (FDRs). The present case-control study A total of 1407 subjects including ACS patients (651) their FDRs (324) along with age and sex matched healthy controls (432) were recruited. Serum IL-10 concentrations and IL-10 gene polymorphisms were evaluated to analyse their association with susceptibility to ACS. Serum IL-10 concentrations were significantly elevated in ACS patients and FDRs (p<0.001) in comparison with controls. IL-10 -1082 AA and -592 CC genotypes were significantly associated with the disease (p<0.001& p=0.0021). FDRs also had shown an increase in frequency of these genotypes when compared to controls (p<0.001). Patients having A-C (1082-592) haplotype was significantly associated with the disease (p=0.034). These results suggest that IL-10 concentrations and its polymorphisms could be involved in the risk of developing ACS in the ACS patients and their FDRs. IL-10 may be a valuable risk factor for prediction in early onset of ACS thus it can be considered as an alternative for other inflammatory markers.