Assessment of melatonergics in prevention of delirium in critically ill patients: A protocol for systematic review and meta-analysis

Background: Delirium is a commonly occurred complication in the critically ill. Melatonin is an endogenous hormone exerting multiple biological effects, mainly in regulating diurnal rhythms, also in inflammatory process and immune response. We aimed to assess the efficacy of exogenous melatonergics in prevention of delirium.