Expression and induction of cytochrome P450 isozymes in hyperplastic nodules of rat liver

The change of cytochrome P450 (P450) isozymes in a early stage of hepatocarcinogenesis in male F344 rats has been studied. Liver microsomes were prepared from normal rats Group 1), rats treated with diethylnitrosamine (DEN) alone, which developed no hyperplastic nodules Group 3), and rats treated with DEN plus 2-acetylaminofluorene, which developed many hyperplastic nodules (group 3)