Antibacterial Effects of Origanum Volatile Oil on Dysentery Bacilli in Vivo and in Vitro

Objective To survey the bacteriostatic and bacteriocidal effects of origanum volatile oil(OVI) on dysentery bacilli. Methods Mice were infected with Shigella sonnei;and Shigella flexneri F_(2a) by intraabdominal inoculation of the bacteria.The protective effect of OVI administered by gastrogavage at different times after the infection on the mice were kept under observation_(.)The minimal inhibitory concentration(MIC) and minimal bactericidal concentration(MBC)of the drug for the dysentery bacilli were determined in vitro. Results The OVI was shown to have an obvious protective effects on the mice infected with Shigella sonnei and Shigella flexneri F_(2a).The drug was also shown to have dramatic bacteriostatic and bacteriocidal effects on different dysentery bacilli in vitro.The MIC and MBC of OVI for dysentry bacilli were 50-100 mg·mL~(-1) and 125-500 mg·mL~(-1),respectively. Conclusion The OVI was shown to be an effective medicine against infection of dysentery bacilli.