Microwave-induced one-pot synthesis of 4-[3-(aryl)-1,2,4-oxadiazol-5-yl]-butan-2-ones under solvent free conditions

Abstract The synthesis of 4-[3-(aryl)-1,2,4-oxadiazol-5-yl]-butan-2-ones ( 5a – l ) from methyl levulinate ( 4 ) and arylamidoximes ( 1a – l ) is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in yields comparable with conventional heating.