Impact factors of serum uPA expressing before and after TACE in patients with primary hepatocelular carcinoma

Objective To investigate the impact factors of serum urokinase type plasminogen activator(uPA) expressing in patients with primary hepatocelular carcinoma(HCC) before and after TACE.Methods Clinical data of 100 patients with HCC were collected,and serum uPA was detected by enzyme-linked immunosorbent assay(ELISA) 3 days before TACE and 3,7,14 and 28 days after TACE,respectively.The impact factors of serum uPA were analyzed by using repeated measure analysis of variance and generalized estimating equations.Results The metastasis of HCC and portal vein thrombus were the major impact factors for the serum uPA content.Conclusion When determining the timing of retreatment of TACE based on serum uPA content,the impact of different prognostic factors,such as portal vein thrombus and HCC metastasis should be taken into consideration.