Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

Jianyang Chen,Haixia Peng,Jin Xue He,Xiajuan Huan,Ze-Hong Miao,Chunhao Yang

Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors.

2014

Jianyang Chen
Haixia Peng
Jin Xue He
Xiajuan Huan
Ze-Hong Miao
Chunhao Yang

Abstract The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biological study of these compounds provided potent compounds 17a , 33b , 33c , 33d , and 33g with low nanomolar IC 50 s against PARP-1 enzyme.

Keywords:

Tricyclic
Enzyme
Poly ADP ribose polymerase
Biochemistry
Organic chemistry
Chemistry
Inhibitory concentration 50
Combinatorial chemistry
Enzyme activator
Stereochemistry
Molecule

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