Total Synthesis of Cannabisin B

Cannabisin B, a naturally occurring lignanamide, has been synthesised for the first time in 15% overall yield. The convergent synthesis is based on the Stobbe reaction and Friedel–Crafts alkylation reaction as the C–C bond-forming steps to afford the skeleton of the lignanamide which was then condensed with 4-methoxyphenethylamine to obtain Cannabisin B.