Alanyl-Glutamine Supplementation in Total Parenteral Nutrition in Gastric Cancer Operation Patients of Nutritional Risk: the Clinical Significance on Immune System,Nutritional Status and Postoperative Recovery

Objective: This research is to evaluate clinical significance of parenteral alanyl-glutamine bipeptide supplementation o-n immunological and nutritional status and postoperative recovery in stomach cancer patients of nutritional risk who received radical ope-ration.Methods: Nutrition risk screening was undertaken by NRS-2002.Sixty patients of over 5 marks were enrolled in this study and were randomized into 2 groups of 30 patients.Parenteral nutritional support was given 5 days before radical gastrectomy.Parental nutrition was continued while only the experiment group was prescribed alanyl-glutamine.Immunological markers,hepatic and renal function markers were monitored by the time of in-charge and 6 days after surgery.The postoperative recovery procedure and complications were carefully recorded.Results: The immune markers of CD4 and CD8 were markedly enhanced in the glutamine group comparing the control groups.There was no significant difference in the incidence of transient hepatic injury.The glutamine group showed a faster albumin restoration,and intestinal peristalsis recovery was also significantly faster in the glutamine group.Diarrhea was less frequent in the glutamine group.Other clinical parameters such as the duration of antibiotic usage,the incidence of postoperative infection revealed no significant differences.Conclusion: For surgical patients with nutritional risk,total parenteral nutrition with glutamine supplementation in the perioperative period may enhance their immune response,promoting postoperative recovery reduce operation complications.