Histologic subtype component predicts lymph node micrometastasis and prognosis in patients with stage I lung adenocarcinoma

Lung cancer is the major cancer-related death in the world. Complete resection is the gold standard for management of early-stage non-small cell lung cancer (1). For extent of pulmonary resection in patients with lung cancer, lobectomy is the standard procedure (2). However, more sublobar resection was done recently due to more small-sized peripheral ground glass nodules were found by chest computed tomography screening. The application of sublobar resection in lung cancer of small size needs more investigation (3). Furthermore, whether radical mediastinal lymph node dissection should be performed in these patients is a controversial issue (3).