Rapidly Fatal Acanthamoeba Encephalitis and Treatment of CryoglobulinemiaMeersseman,* Katrien Lagrou,*

We describe a 66-year-old woman with therapy-refractory cryoglobulinemia treated with rituximab, plasmapheresis, and steroids; a case of fatal meningoencephalitis caused by Acanthamoeba spp. then developed. Such infections are rare and show an unusually rapid course (possibly related to rituximab).