Comparison of the remifentanil and remifentanil+propofol combination for sedoanalgesia in functional endoscopic sinus surgery

Background: We aimed to compare the remifentanil and remifentanil + propofol combination for sedoanalgesia in functional endoscopic sinus surgery performed under local anesthesia. Methods: Forty patients from American Society of Anesthesiologists (ASA) I-II patients between the ages of 18-70 years were divided randomly into two groups. The 1st group (n=20) received 1 mcg/kg remifentanil bolus and 0.1 mcg/kg/min infusion and the 2nd group (n=20) received 0.5 mcg/kg remifentanil bolus, 0.05 mcg/kg/min infusion and 50 mcg/kg/min propofol. Systolic, diastolic, mean arterial pressure, heart rate, respiratory rate, and SpO2 values, discomfort scores, verbal response to pain, OAA/S (Observer’s Assessment Alertness/ Sedation) scale, Aldrete recovery scores, and side effects were recorded at particular intervals. Results: There was no difference between groups hemodynamically. The doses used in each group showed adequate levels of sedation. 0.1 mcg/kg/min remifentanil provided better analgesia; however, the respiratory rate was reduced and nausea and vomiting were increased. Conclusion: We believe that either remifentanil or remifentanil + propofol combination can be used safely during functional endoscopic sinus surgery operations for sedoanalgesia in monitored anesthetic care at determined dose intervals.