Effect of Tarivid (Ofloxacin) on otorhinolaryngological infections.

In recent years, the number of adults with acute deterioration of chronic otorhinolaryngological infections has been increasing.Problems that we encounter in the treatment of chronic otorhinolaryngological infections include an increase of drug-resistant bacteria and unsatisfactory penetration of drugs into the tissues. The authors recently used Tarivide (ofloxacin), a new drug of the quinolone family, to treat 20 patients with acute deterioration of chronic otorhinolaryngological diseases (tonsillitis, nasosinusitis and tympanitis). The drug proved to be clinically effective in 95.0% and bacteriologically effective in 88.2% of the 20 patients. In 6 patients who were treated with this drug preoperatively, the blood and tissue concentrations of the drug were high.These results indicate that ofloxacin can be useful for the treatment of chronic infections in the field of otorhinolaryngology.