Synthesis, anti-proliferative and genotoxicity studies of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones and 6-chloro-5-(2-chloroethyl)-3-(alkyl/ary-2-ylidene)indolin-2-ones.

Abstract A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2 H -indol-2-ones ( 3a-h ) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones ( 5i-x ) were synthesized. Compounds 3a - e , 5i - l and 5q - r were selected by NIH, USA for in vitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a - b and 3e which showed growth inhibition in the range 1.22–76.30%, 2.85–76.03% and 10.98–82.05% respectively at 10 −5 concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.