Muramyl peptide analogs : Synthesis of a depsipeptide using orthogonal SPPS

Abstract A depsipeptide mimic of the Gram-positive muramyl peptide was synthesized on resin using both Boc and Fmoc protection strategies. The depsipeptide unit is chemically and stereochemically compatible with both Boc and Fmoc chemistries and with HF cleavage conditions.