Early growth of regenerating neurites in acrylamide neuropathic mice: application of a film model

Abstract Acrylamide intoxication markedly impairs neural regeneration following transection of a peripheral nerve. However, no neural inhibitory mechanism has yet been clarified. In the present study, the early growth of regenerating neurites in acrylamide neuropathic mice was analyzed using a film model: following transection of the common peroneal nerve, the proximal stump was sandwiched between two sheets of thin plastic film and kept in vivo for various intervals after axotomy. The regenerating axons grew for a significantly ( P