Influence of isotropic skull models on EEG source localization

We investigated the influence of using simplified skull models on electroencephalogram (EEG) source localization. The simplified skull models were derived from CT and MR images, with isotropic conductivity modeled as either heterogeneous or homogeneous. A total of four simplified head models were compared against a reference model with a skull accurately segmented with CT images. Our results show that the use of a simplified geometry for the skull, can lead to errors of approximately 1 cm for sources located in the central and temporal regions of the brain.