LDL cholesterol is associated with systemic vascular resistance and wave reflection in subjects naive to cardiovascular drugs
2019
Background and aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated hypertensive subjects.Methods: We recruited 615 volunteers (19–72 years) without lipid-lowering and BP-lowering medication. Supine haemodynamics were recorded using continuous radial pulse wave analysis, whole-body impedance cardiography, and single channel electrocardiogram. The haemodynamic relations of LDL-C were examined using linear regression analyses with age, sex, body mass index (BMI) (or height and weight as appropriate), smoking status, alcohol use, and plasma C-reactive protein, sodium, uric acid, high density lipoprotein cholesterol (HDL-C), triglycerides, estimated glomerular filtration rate, and quantitative insulin sensitivity check index as the other included variables.Res...
Keywords:
- Cardiology
- Internal medicine
- Impedance cardiography
- Vascular resistance
- High-density lipoprotein
- Body mass index
- Low-density lipoprotein
- Cholesterol
- Medicine
- Quantitative insulin sensitivity check index
- Blood pressure
- elevated blood
- Hemodynamics
- low density lipoprotein cholesterol
- Risk factor
- ldl cholesterol
- Diabetes mellitus
- Correction
- Source
- Cite
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