Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

A genome-wide RNAi screen reveals the importance of local pH regulation during planar epithelial polarization. The plasma membrane association of the planar cell polarity components Dishevelled/Frizzled depends on the activity of the Na+/H+ membrane exchanger Nhe2.