Сравнительная характеристика нейропротекторных свойств глицина и магния сульфата у крыс с использованием морфометрических, иммуноферментных и неврологических методов оценки повреждения головного мозга

Neuroprotective properties of magnesium sulphate and glycine were confirmed using the model of focal ischemia of the left middle cerebral artery followed by 24-hour reperfusion in rats. Magnesium sulfate (90 mg/kg, IV, 30 minutes before ischemia) reduced the level of NSE by 67 %, cerebral edema by 25 %, yielded a 1,9-time reduction in the necrosis zone area and improved neurological symptoms by 23,4 %. Glycine (800 mg/kg, IP, 30 minutes before ischemia) suppressed an increase in the NSE concentration by 114 %, yielded a 2.24-time reduction in the necrotic zone area and decreased the degree of cerebral edema by 32 %, and improved neurological symptoms by 23 %.