Glibenclamide tablet and preparation method thereof

The invention discloses a glibenclamide tablet and a preparation method thereof. The preparation method comprises the following steps of: 1) uniformly mixing microcrystalline cellulose, mannitol and low substituted hydroxy propyl cellulose in a predetermined amount to obtain mixed power I; 2) adding an aqueous solution containing hydroxypropyl methylcellulose E50 in a predetermined amount to the mixed powder I to prepare fine sand hollow particles; 3) drying and screening the hollow particles; 4) mixing glibenclamide with 15-20% of hollow particles according to an equivalent progressively increase method to obtain mixed powder II; 5) uniformly mixing the mixed powder II and residual hollow particles to obtain mixed powder III; 6) uniformly mixing the mixed powder III with magnesium stearate to obtain mixed powder IV; and 7) tabletting the mixed powder IV according to predetermined weight of tablets to prepare the glibenclamide tablet. The glibenclamide tablet and the preparation method disclosed by the invention solve the problem that glibenclamide is sensitive to damp and hot and the problem of content uniformity, so that the dissolution rate of the glibenclamide tablet is improved.