Comparative Genomic Hybridization

Comparative genomic hybridization (CGH) allows the entire genome of an organism to be scanned for relative changes in DNA copy number (copy number aberrations) (1–3) in a single experiment. Standard CGH can detect aneuploidies, deletions, and unbalanced translocations at a resolution of 5–10 megabases. This is particularly useful in cases where DNA is unstable and where changes in copy number occur. Thus, tumors are often analyzed by CGH, but other applications could include diagnosis of other chromosome based illnesses.