Misoprostol for the termination of pregnancy up to 12 completed weeks of pregnancy

The aim was to review the current knowledge about the use of misoprostol alone for abortion induction during the first 12 weeks of pregnancy. Publications reporting experiences with misoprostol alone for pregnancy termination within the first 12 weeks of pregnancy were included in the analysis.Vaginaladministration of 800 μg repeatedupto threetimes at6,12or24h intervals has an 85% to 90% effectiveness, defined as complete abortion,in most studies. Oraladministration is less effective, but sublingual administration at 3-hour interval has the same effectiveness, with more frequent side effects. The oral and sublingual routes appear to be better accepted than