Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.
2003
Abstract Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus . Structure–activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo.
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