N‐(3‐Chloro‐2‐hydroxypropyl)‐valine in blood as haemoglobin adduct of epichlorohydrin [Biomonitoring Methods, 2013]

Published in the series Biomonitoring Methods, Vol. 13 (2013) The article contains sections titled: General principles Equipment, chemicals and solutions Equipment Chemicals Solutions Internal standard Calibration standards Specimen collection and sample preparation Preparation of the erythrocyte lysate Isolation of the globin Derivatisation of the globin Operational parameters Operational parameters for gas chromatography Operational parameters for tandem mass spectrometry Analytical determination Calibration Calculation of the analytical result Standardisation and quality control Evaluation of the method Precision Accuracy Detection limit and quantitation limit Sources of error Discussion of the method Appendix Keywords: determination in blood; capillary gas chromatography; tandem mass spectrometric detection; GC/MS/MS; analysis in biological materials; occupational monitoring; analytical method; biomarker; metabolites