A novel method for measuring the hydraulic conductivity of tumor tissue

Resistance against drug delivery is a challenge in oncology. The elevated interstitial fluid pressure (IFP) in solid tumors has been identified as a barrier for drug transport. Also, the hydraulic conductivity (K) of tumor stroma strongly correlates with the IFP. However, values of K in human cancer tissue are not available. Here, we developed a novel in vitro setup that allows to measure K in clinical samples.