Secondary metabolites from the Chinese liverwort Diplophyllum apiculatum

Abstract Three new clerodane-type diterpenoids, diplapiculins A–C ( 1 - 3 ), together with five known compounds ( 4 - 8 ) were isolated from the Chinese liverwort Diplophyllum apiculatum (A. Evans) Stephani. Their structures were determined by detailed analysis of HRMS and NMR data, coupled with single-crystal X-ray diffraction crystallography and electronic circular dichroism (ECD). They were found no antifungal and anticancer effects in preliminary biotests in vitro.