Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
2010
Munc13 primes synaptic vesicles for exocytosis. Studies now reveal that the central C2B domain of Munc13 contains a structurally unusual Ca2+ binding site that confers specific phospholipid-binding properties to Munc13 and is essential for regulating exocytosis upon trains of action potentials.
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