Interleukin- $1{\beta}$ Decreases Caveolin-1 Expression in Human Nasal Epithelium

Background and Objectives：Caveolin-1 (Cav-1) is the structural protein that is necessary for the formation of caveolae mem-atherosclerosis, restrictive lung disease and obesity. However, studies for Cav-1 in nose has been hardly performed. The objectives of our study were to detect Cav-1 expression in human nasal epithelium and to investigate the change of Cav-1 expression in the inflamation of nasal epithelium. Subjects and Method：We obtained nasal polyp specimens from thre patients undergoing endoscopic sinus surgery. Cells from specimens were cultured using the air-liquid interface technique and IL-1β was treated. The (RT-PCR) and western blot analysis, respectively. Results：Both RT-PCR and Western blot analysis demonstrated the presence of Cav-1 mRNA and protein in human nasal epithe-lium. Furthermore, the expresion of both Cav-1 mRNA and protein was decreased by IL-1β stimulation. Conclusion：Cav-1 was expressed in human nasal epithelial cels. It is asumed that Cav-1 may play a role in nasal inflamatory disease. However, further studies to confirm the interaction betwen Cav-1 and signaling molecules in the nasal (Korean J Otorhinolaryngol-Head Neck Surg 2008 ;51 :46-50)