Fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation
2019
Objective
To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT) .
Methods
Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT. One of them was refractory intestinal infection, the others were intestinal graft versus host disease. One or two doses of fecal microbiota, 3.4-6.0 U for one dose, were infused via nasal-jejunal tube. The curative effect and side effects were reviewed.
Results
Three cases achieved complete remission while 1 was stable disease. The side effects included fever, abdominal pain and diarrhea, which all were Ⅰ grade.
Conclusion
Fecal microbiota transplantation was effective and safe for refractory diarrhea after allo-HSCT.
Key words:
Hematopoietic stem cell transplantation; Diarrhea; Graft versus host disease; Fecal microbiota transplantation
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