SIRT1 in Colorectal Cancer: A Friend or Foe?

It has been well established that SIRT1 plays a key role in the regulation of various crucial biological processes such as apoptosis, DNA damage response, cell senescence and metabolism. However, its role in Colorectal carcinogenesis is still subject to debate. In this study, we uncover a double role of SIRT1 in colorectal carcinoma