Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.

Frederic Leroy,Dominique Chaves,David Dukhan,Richard Storer,Jean-Pierre Sommadossi,Anna Giulia Loi,Alessandra Cadeddu,Maura Fanti,Nadia Boscu,Fabiola Bassetti,Michel Liuzzi,Gilles Gosselin

Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.

2008

Frederic Leroy
Dominique Chaves
David Dukhan
Richard Storer
Jean-Pierre Sommadossi
Anna Giulia Loi
Alessandra Cadeddu
Maura Fanti
Nadia Boscu
Fabiola Bassetti
Michel Liuzzi
Gilles Gosselin

Three 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives were synthesized and evaluated as potential inhibitors of RNA virus replication, including hepatitis C virus (HCV).

Keywords:

2-Aminopurine
Hepatitis C virus
Nucleoside
Chemistry
Virology
Hepacivirus
RNA virus

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