Response to Angiotensin-(1–7) and Kidney Disease: Friend or Foe

We appreciate Velkoska et al for their interests in our recent publication concerning the effects of angiotensin (Ang)-(1–7) in the rostral ventrolateral medulla (RVLM) on enhanced cardiac sympathetic afferent reflex (CSAR) and sympathetic activation in 2-kidney, 1-clip renovascular hypertensive rats.1 Indeed, as Velkoska et al have indicated the effects of Ang-(1–7) in patients or experimental models of kidney diseases are controversial.2 Some studies indicate that, as a counter regulator of the classic Ang II/Ang II type 1 (AT1) receptor axis–mediated effects, Ang-(1–7)/Mas receptor axis is expected to play a potential therapeutic role in kidney …