Origins of Cardiorenal Syndrome and the Cardiorenal Connection

In recent years, the relationship between the heart and the kidneys in disease has received increasing attention from the clinical and scientific medical community. This was initiated by epidemiological observations in the late 1990’s of increasing patient numbers with concurrent heart and kidney problems, and the association with a significantly higher mortality ratio. This has led to intense discussions about the value of the recognition of cardiorenal disease on the one hand, and the existence of a specific “cardiorenal syndrome” on the other hand.1-10