Synthesis of systematic reviews of percutaneous device closure of patent foramen Ovale (PFO) for prevention of recurrent cryptogenic stroke: Redundant publications and Methodologic deficiencies

Abstract Critical assessments of SR/MAs have found them to often be redundant, lacking in novel perspectives, of poor methodological quality, and written by authors with potential conflicts of interest. We sought to investigate these issues as they relate to SR/MAs of percutaneous patent foramen ovale (PFO) closure for the prevention of recurrent cryptogenic stroke.