In vitro action of new organometallic compounds against trypanosomatidae protozoa

The effects of 10 newly synthesized organonretalic rhodium complexes (5 of Rh (I), 4 of Rh (III) and one of Rh (IV) complex salt) and 2 antimony (III) complexes against epimastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania donovani have been studied in vitro. Of the 10 rhodium complexes tested three proved 100% efficient in inhibiting the growth of the epimastigote forms of T cruzi while only one worked against the pronrastigote forms of L. donovani. The two antimony complexes inhibited the growth of L. donovani totally and were fairly successful against T cruzi