Deuterated triazolam and preparation method thereof

The present invention discloses deuterated triazolam and preparation method thereof, the preparation method of deuterated triazolam, comprise the steps: that (1) is by chloro-for 8-6-(2-chloro-phenyl-)-1-methyl-4H-[1,2,4] triazole also [4,3-a] [Isosorbide-5-Nitrae] benzodiazepine join dimethyl sulfoxide (DMSO) or N, mix in dinethylformamide, stir; (2) add cesium carbonate or salt of wormwood as catalyzer, and add deuterochloroform, be heated to more than 40 degrees Celsius, stir; (3) deuterated triazolam is separated to obtain.Preparation method of the present invention is brief, easy and simple to handle, with low cost, easy purifying.By commercially available non-deuterated triazolam in non-deuterated solvent atmosphere, doing deuterium source with a small amount of deuterated reagent, obtaining deuterated triazolam in the short period, by obtaining sterling after simple column chromatography purification.The deuterated triazolam standard substance purity prepared according to the present invention is high, stable chemical nature; Can conveniently for the preparation of analysis standard substance.The deuterated internal standard substance that preparation method of the present invention uses when can be used for production analyzing and testing triazolam.