Approach to the synthesis of nogalarol via the cycloaddition of a carbene-chromium complex with a functionalized alkyne

Abstract The alkyne, 4 , prepared stereoselectively in 7 steps from acetyl furan, reacts with (methoxy)(phenyl)carbenepentacarbonylchromium(0), 15 , to give the model ( 16 ) for nogalarol ( 1b ) in 43% yield.