Hypotensive action of cuzhuangnuzhen (Ligustrum robustum)

When an extract of the leaves of Ligustrum robustrum was given to anesthetized rats intravonously at doses of 0.098, 0.140, 0.200 g/kg the BP of the animals decreased repaidly by 37.7, 38.6 and 50.2% respectively. But withoug any effect when given intragastrically to conscious rats at 1.36g/kg (qid×3d). When conscious spontaneous hypertensive rats were given this extract intrastrically at 1.08 and 2.16g/kg (qid×5d) their BP decreased to 18.1±0.9 and 16.6±.kPa from 24.3±0.5 and 24.3±0.6kPa respectively (P<0.001, P<0.001). When 2 kidney 1 clip hypertensive rats were treated with this extract ig at 0.5g/kg (qid×7d), the BP decreased to 16.2±3.9kPa from 20.3±3.9kPa.