Reversal of effects on the rat nerve-diaphragm preparation produced by methylfluorophosphorylcholines

Abstract The effects of four organophosphorylcholines (methylfluorophosphoryl-choline, methylfluorophosphoryl-β-methylchol ine, methylfluorophosphorylhomocholine and methylfluorophosphorylcarbocholine (3:3-dimethylbutoxyphosphoryl fluoride)) and methyl iso propoxyphosphoryl fluoride (Sarin) on the rat nerve-diaphragm preparation have been studied together with the reversal of these effects by various reactivators (2-PAM, MINA, DINA). Sarin and the carbocholine analogue produced neuromuscular block more rapidly than did the quaternary nitrogen compounds. Neuromuscular block produced by Sarin was the easiest to reverse; the reactivators had less effect on the block produced by the organophosphorylcholines particularly in the case of the homocholine analogue.