Isavuconazole sulfate crystal and preparation method thereof

The invention relates to an isavuconazole sulfate crystal form, and a preparation method and a medicinal composition thereof. The crystal form has the advantages of good stability, high purity, good reappearance and suitableness for preparing medicinal preparations. The preparation method comprises the following steps: dissociating isavuconazole hydrochloride by using an alkali, carrying out salt exchange by using concentrated sulfuric acid and hydrogen peroxide, and carrying out re-crystallization. The method has the advantages of mild reaction conditions, simple post-treatment and high purity of the above product, and meets basic requirements of industrial amplified production.