[Clinical and experimental results on the significance of kidney damage for long-term prognosis after kidney transplantation].

: In the clinical study the influence of the differently long times of warm ischaemia and of the duration of the acute renal insufficiency post transplantationem on the late prognosis of the grafts and the survival of the patients as well as on the incidence of complications in 93 patients who first underwent a transplantation of the CD-kidney and who more than two months after the transplantation lived with a working kidney was examined. A direct relation between the duration up to the beginning of the function of the kidney and the long-term prognosis of the patients was proved. In the group with immediate beginning of the function of the kidney at an average WIZ of 13 minutes the creatinine clearance was significantly higher and the incidence of severe infections in the late phase was lower than in the groups with longer WIZ and very retarded beginning of the renal function. Haemodynamic investigations on the autograft model of the dog after 30 minutes WIZ resulted in a pathologically increased renal vascular resistance and in a restricted filtration function up to 4 weeks post transplantationem.