Labeling of NGR Peptide With ~(188)Re and Its Biodistribution and SPECT Imaging in Tumor-bearing Nude Mice

To evaluate its radiochemical characteristics,biodistribution and imaging for nude mice bearing HepG2,188Re-NGR was prepared directly with 2-mercapto-ethanol as reductant and sodium gluconate as middle ligand.The labeling yield of 188Re-NGR was more than 85%,and the radiochemical purity(RCP) was more than 90%.In vivo,188Re-NGR can specifically bind with tumor.The tumor uptake was(2.84±0.51)%ID/g at 1 h after injection,the uptake was(4.62±0.71)%ID/g at 12 h and remains(2.01±0.38)%ID/g for 24 h,the contrl group was(1.43±0.61)%ID/g.The ratio of tumor to muscle was 4.76 at 12 h.The xenografted tumor became visible at 1 h and was the most clearly at 12 h.The results showed that NGR had the function of good targeting.