Effect of Curcumin on TGF-β Receptor of Human Embryo Lung Fibroblast

Objective By adopting MRC-5 induced by transforming growth factor 1(TGF-β1),to explore the effect and mechanisms of curcumin on pulmonary fibrosis from molecular level in vitro and discuss the preventing and treating effect of curcumin on pulmonary fibrosis.Methods The MRC-5 were divided into four groups:normal group,curcumin group,TGF-β group,TGF-β+cucurmin group.The expression of TGF-β RⅠ,TGF-β RⅡ were tested by the Real-time PCR and Western blotting.Results The expression of TGF-β RⅠ and TGF-β RⅡ in TGF-β+cucurmin group was significantly decreased compared with normal group and TGF-β1 group.Conclusions Curcumin can inhibit the MRC-5's collagen deposition which may have important role in delaying lung fibrosis forming progress.Its mechanism may be related with inhibiting TGF-β RⅠand TGF-β RⅡ.