Clinical characteristics of several patients with coronavirus disease 2019 in Lanzhou City/ 兰州市部分新型冠状病毒肺炎患者病例特征

Objective To investigate and summarize the clinical and imaging features of a few patients with coronavirus disease 2019 (COVID-19) in Lanzhou City Methods We carried out a retrospective analysis of the epidemiological data, laboratory results and clinical imaging features of eight hospitalized patients with confirmed COVID-19in The First Hospital of Lanzhou University from January 23 to February 23, 2020 Results The sex ratio (men to women) of the 8 patients was 5:3 while their age ranged from 24 to 57 years old The incubation period was 1-10 days Of the 8 patients, 7(87 5%) had COVID-19 brought in from other places in China and 1(12 5%) was a secondary infection case The main clinical manifestations included cough in 6 cases (75%), fever in 4 cases (50%), expectoration in 3 cases (37 5%), and fatigue in 2 cases (25%) All the 8 cases indicated abnormal manifestations in blood routine examinations, 4cases (50%) decreased in WBC, 7 cases (87 5%) decreased in Lym count, 5 cases (62 5%) increased in LDH, 1 case (12 5%) increased in CK, 1 case (12 5%) increased in CK-MB, 4 cases(50%) increased in CRP, 2 cases(25%) increased in PCT, and 1 case (12 5%)increased in D-dimer Of the 2patients examined by chest digital radiography (DR), one DR finding was not typical and the other one suggested increased bilateral lung markings Six patients were examined by HRCT, of whom four (50%) showed multiple ground glass opacities on both lobes and two (25%) showed multiple ground glass opacities only on the right lobe;none of the 6 imaging findings suggested pleural effusion Seven patients were discharged from hospital after being cured and 1 patient is still undergoing treatment Conclusion Most of these 8 patients had COVID-19brought from outside the city, and the patients were relatively young with few underlying diseases Their major symptoms were fever, cough, and expectoration All of them exhibited abnormal findings in blood routine examinations;half of them suggested increased CRP while a few ones showed abnormal CK and Ddimer values The imaging manifestations of most patients were multiple ground glass opacities near the peripheral pleura